Justin Benesch
Tutorial Fellow in Physical Chemistry; Professor of Biophysical Chemistry
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Teaching
Teaching experience including lecturing undergraduates and graduates in biophysics and physical chemistry, tutoring in undergraduate physical chemistry, coordinating seminar series for PhD students, and outreach teaching in schools in the UK and developing world.
Research
Justin鈥檚 research has garnered an international reputation for innovative biophysical chemistry approaches based on combining mass measurement with other experimental methods, simulations, and quantitative thermodynamic and kinetic analyses. This has allowed him and his group to change our thinking as to how proteins assemble, interact, and even evolve.
After a degree in Chemistry at the University of Oxford, Justin obtained his PhD from the University of Cambridge for the development and application of novel mass spectrometry approaches. He was awarded fellowships from the Medical Research Council and Royal Society, and appointed to faculty at the University of Oxford in 2012 as an Associate Professor in Biophysical Chemistry, and Tutorial Fellow in Physical Chemistry at 182t福利. Justin has been recognised by the Cell Stress Society International with the Alfred Tissi猫res Award, the Howard Prize Lecture from the Biophysical Sciences Institute at Durham, and the Norman Heatley Award from the Royal Society of Chemistry in 2019.
His group鈥檚 research impacts broadly the interface between chemistry and the life sciences. Their insights have been important to understanding molecular chaperone (mal)function in humans, and the stress tolerance of plants; and their innovations in mass measurement approaches have provided new means for researchers to quantify biomolecules and their interactions.
Selected Publications
鈥� Collier, M.P., Alderson, T.R., de Villiers, C.P., Nicholls, D., Gastall, H.Y, Allison, T.M., Degiacomi, M.T., Fuerst, D.O., van de Ven, P.F.M., Djinovic-Carugo, K., Baldwin, A., Watkins, H., Gehmlich, K., Benesch, J.L.P. 鈥淗SPB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C鈥� – Science Advances, (2019), 5, eaav8421
鈥� Malay, A.D., Miyazaki, N., Biela, A., Chakraborti, S., Majsterkiewicz, K., Stupka, I., Kaplan, C.S., Kowalczyk, A., Piette, B.M.A.G., Hochberg, G.K.A., Wu, D., Wrobel, T.P., Fineberg, A., Kushwah, M.S., Kelemen, M., Vavpeti膷, P., Pelicon, P., Kukura, P., Benesch, J.L.P., Iwasaki, K., Heddle, J.G. 鈥淎n ultra-stable gold-coordinated protein cage displaying reversible assembly鈥� – Nature, (2019), 569, 438-42
鈥� Alderson, T.R., Roche, J., Gastall, H.Y., Priti拧anac, I., Ying, J., Bax, A., Benesch, J.L.P.*, Baldwin, A.J. 鈥淟ocal unfolding of the HSP27 monomer regulates chaperone activity鈥� – Nature Communications (2019), 10, 1068
鈥� Lyon, Y.A., Collier, M.P., Riggs, D.L., Degiacomi, M.T., Benesch, J.L.P.*, Julian, R. 鈥淪tructural and functional consequences of age-related isomerization in 伪-crystallins鈥� Journal of Biological Chemistry, (2019), 294, 7546-55, and bioRxiv 364497; doi:10.1101/364497
鈥� Young, G., Hundt, N., Cole, D., Fineberg, A., Andrecka, J., Tyler, A., Olerinyova, A., Ansari, A., Marklund, E.G., Collier, M.P., Chandler, S.A., Tkachenko, O., Allen, J., Crispin, M., Billington, N., Takagi, Y., Sellers, J.R., Eichmann, C., Selenko, P., Frey, L., Riek, R., Galpin, M.R., Struwe, W.B., Benesch, J.L.P.*, Kukura, P. 鈥淨uantitative mass imaging of single biological macromolecules鈥� – Science (2018) 360 (6387), 423-427
鈥� Hochberg, G.K.A., Shepherd, D.A., Marklund, E.G., Santhanagoplan, I., Degiacomi, M.T., Laganowsky, A., Allison, T.M., Basha, E., Marty, M.T., Galpin, M.R., Struwe, W.B., Baldwin, A.J., Vierling, E., Benesch, J.L.P. 鈥淪tructural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions鈥� – Science (2018), 359, 930-5
鈥� Hilton, G. R., Hochberg, G., Laganowsky, A., McGinnigle, S. I., Baldwin, A.J., Benesch, J.L.P 鈥淐-terminal interactions mediate the quaternary dynamics of 伪B-Crystallin 鈥� – Philosophical Transactions of the Royal Society B, (2013), 368, 20110405
鈥� Stengel, F., Baldwin, A.J., Bush, M.F., Hilton, G.R., Lioe, H., Basha, E., Jaya, N., Vierling, E., Benesch, J.L.P. 鈥淒issecting heterogeneous molecular chaperone complexes using a mass spectrum deconvolution approach鈥� – Chemistry & Biology, (2012), 19, 599-607
鈥� Baldwin, A.J., Lioe, H., Hilton, G., Bagn茅ris, C., Baker, L.A., Rubinstein, J.L., Kay, L.E., Benesch, J.L.P. 鈥淭he polydispersity of 伪B-crystallin is rationalized by an inter-converting polyhedral architecture鈥� – Structure (2011), 19, 1855-63
鈥� Stengel, F., Baldwin, A.J., Painter, A.J., Jaya, N., Basha, E., Kay, L.E., Vierling, E., Robinson, C.V., Benesch, J.L.P. 鈥淨uaternary dynamics and plasticity underlie small heat shock protein chaperone function鈥� – Proceedings of the National Academy of Sciences USA (2010) 107, 2007-12